Paullinia cupana Seed

Paullinia cupana Seed

Proposed For Development Version 0.1

Paullinia cupana Seed


 

DEFINITION

The article consists of the dried ripe seeds of Paullinia cupana Kunth (Family Sapindaceae), collected in April and May. It meets the Acceptance criteria under the Assay.

 

SYNONYMS

Paullinia sorbilis Mart.

 

POTENTIAL CONFOUNDING MATERIALS

Paullinia cuneata Radlk.

Paullinia yoco R. E. Schult. & Killip

 

SELECTED COMMON NAMES

Dutch: Guaranastruik

English: Guarana, Brazilian cocoa

German: Guarana, guarana kletterstrauch

Portuguese: Guaraná

Spanish: Guaraná

Swedish: Guarana

 

CONSTITUENTS OF INTEREST

Methylxanthines: Caffeine, theobromine, and theophylline

 

IDENTIFICATION

• A. Botanical Characteristics

Macroscopic: Seeds are black and partly covered with a white arils.

Microscopic

Transverse section: Testa; epidermis elongated cells with U-shape thickening; dark brown, tangentially elongated parenchyma cells with scattered sclereids; the innermost layer of the testa consists of slightly thickened and pitted cells; at the hilum, the testa is composed of several layers of isodiametric sclereids. Embryo; epidermis, thin-wall cells; polygonal or roundish parenchyma cells with small intercellular spaces; cells close to the epidermis have yellow-brown walls and those further to the interior have colorless walls, starch granules are abundant.

B. Thin-Layer Chromatography

CALL FOR SUBMISSION OF VALIDATED INFORMATION

 

Additional information including validation data will be required to complete the development of the Identification test. For requirements, please see under "Identification" and related sections of the guidelines document “Monographs in the Herbal Medicines Compendium” at http://hmc.usp.org/about/general-noticesguidelines.

 

Interested parties are encouraged to submit their proposals to complete the monograph.

 

ASSAY

• Content of Constituents of Interest

CALL FOR SUBMISSION OF VALIDATED INFORMATION

 

Additional information including validation data will be required to complete the development of the Assay. For requirements, please see under "Composition" and related sections of the guidelines document “Monographs in the Herbal Medicines Compendium” at http://hmc.usp.org/about/general-noticesguidelines.

 

Interested parties are encouraged to submit their proposals to complete the monograph.

 

CONTAMINANTS

• Articles of Botanical Origin, General Method for Pesticide Residues Analysis <561>: Meets the requirements

• Microbial Enumeration Tests <61>: The total aerobic bacterial count does not exceed 105 cfu/g, the total combined molds and yeasts count does not exceed 103 cfu/g, and the bile-tolerant Gram-negative bacteria does not exceed 103 cfu/g.

• Tests for Specified Microorganisms <62>: Meets the requirements of the tests for the absence of Salmonella species and Escherichia coli

 

ADDITIONAL REQUIREMENTS

• Packaging and Storage: Preserve in well-closed containers, protected from light and moisture, and store at room temperature.

• Labeling: The label states the Latin binomial and the part of the plant contained in the article.

• USP Reference Standards <11>

TO COME

 

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