Antrodia camphorata Fruiting Body

Antrodia camphorata Fruiting Body

Proposed For Development Version 0.1

Antrodia camphorata Fruiting Body

 


 

DEFINITION

The article consists of the dried fruiting bodies of Antrodia camphorata (M. Zang & C.H. Su) Sheng H. Wu, Ryvarden & T.T. Chang (Family Polyporaceae). It contains NLT 5% of triterpenoic acid, calculated as the sum of antcin A; antcin B; antcin C; antcin H; antcin K; 1,4-dimethoxy-2,3-methylenedioxy-5-methylbenzene; dehydrosulfurenic acid; and dehydroeburicoic acid on the dried basis.

 

SYNONYMS

Antrodia cinnamomea T.T. Chang & W.N. Chou

Taiwanofungus camphoratus (M. Zang & C.H. Su) Sheng H. Wu, Z.H. Yu, Y.C. Dai & C.H. Su

 

POTENTIAL CONFOUNDING MATERIALS

Ganoderma camphoratum

 

SELECTED COMMON NAMES

Chinese: 牛樟芝 (niu-chang-ku)

 

CONSTITUENTS OF INTEREST

Triterpenoids: Antcin A; antcin B; antcin C; antcin H; antcin K; 1,4-dimethoxy-2,3-methylenedioxy-5-methylbenzene; dehydrosulfurenic acid; and dehydroeburicoic acid

 

IDENTIFICATION

• A. Botanical Characteristics

Macroscopic: Fruiting body is 10–15 cm broad, 0.5–1 cm thick, red to light-cinnamon, resupinate, effused-reflexed to pileate, very bitter taste, cylindrical basidiospores, and weakly amyloid skeletal hyphae; effused-reflexed to more or less triquetrous, and elongated to semicircular. This basidiocarp is tightly attached to the lateral base and may form subpendant and irregular; sterile in margin, corky to woody, and very bitter taste. Upper surface of the basidiocarp at first colors with orange-red and organizes orange-brown to light-cinnamon resinous layer. Further, this surface character persists over the younger marginal areas, becoming brown or blackish, glabrous, concentrically-zoned, and sulcate; the margin of the surface is obtuse, deflexed, and undulate. Pore is round to angular, 4–6 mm; pore surface is orange-red, but orange-brown to light-cinnamon in young specimens, and cream-colored to buff in old specimens. Context is lacking or very thin and concolorous with the pore surface; tube is up to 40 mm long, not stratified, and concolorous with the pore surface.

Microscopic: The hyphae are generative with 2.0–3.5 µm clamp connections, and hyaline to light-brown skeletal hyphae are up to 4.5 µm wide with weak amyloid. Basidia, 12–14 x 3–5 µm, are clavate and 4-sterigmate with a basal clamp. Basidiospores, 3.5–5.0 x 1.5–2.0 µm, are cylindrical, hyaline, smooth, and sometimes slightly bent.

• B. Thin-Layer Chromatography

 

CALL FOR SUBMISSION OF VALIDATED INFORMATION

 

Additional information including validation data will be required to complete the development of the Identification. For requirements, please see under “Identification” and related sections of the guidelines document “Monographs in the Herbal Medicines Compendium” at http:// hmc.usp.org/about/general-noticesguidelines.

 

Interested parties are encouraged to submit their proposals to complete the monograph.

 

ASSAY

• Content of Triterpenoids

 

CALL FOR SUBMISSION OF VALIDATED INFORMATION

 

Additional information including validation data will be required to complete the development of the Assay. For requirements, please see under “Composition” and related sections of the guidelines document “Monographs in the Herbal Medicines Compendium” at http:// hmc.usp.org/about/general-noticesguidelines.

 

Interested parties are encouraged to submit their proposals to complete the monograph.

 

CONTAMINANTS

Elemental Impurities—Procedures <233>

Acceptance criteria

Arsenic: NMT 2.0 µg/g

Cadmium: NMT 1.0 µg/g

Lead: NMT 5.0 µg/g

Mercury: NMT 0.2 µg/g

Articles of Botanical Origin, General Method for Pesticide Residues Analysis <561>: Meets the requirements

Microbial Enumeration Tests <61>: The total aerobic bacterial count does not exceed 105 cfu/g, the total combined molds and yeasts count does not exceed 103 cfu/g, and the bile-tolerant Gram-negative bacteria does not exceed 103 cfu/g.

Tests for Specified Microorganisms <62>: Meets the requirements of the tests for the absence of Salmonella species and Escherichia coli

Articles of Botanical Origin, Test for Aflatoxins <561>: Meets the requirements

 

SPECIFIC TESTS

Articles of Botanical Origin, Alcohol-Soluble Extractives, Method 1 <561>: NLT 20%

Articles of Botanical Origin, Water-Soluble Extractives, Method 2 <561>: NLT 8.0%

Loss on Drying <731>

Sample: 1.0 g Antrodia camphorata Fruiting Body, finely powdered

Analysis: Dry at 105° for 4 h.

Acceptance criteria: NMT 75%

Articles of Botanical Origin, Total Ash <561>: NMT 4%

 

ADDITIONAL REQUIREMENTS

Packaging and Storage: Preserve in well-closed containers, protected from light and moisture, and store at room temperature.

Labeling: The label states the Latin binomial and the part(s) of the plant contained in the article.

USP Reference Standards <11>

USP Aflatoxins RS

USP Antrodia camphorata Fruiting Body Dry Extract RS

USP Dexamethasone RS

The commenting period for this monograph has expired.

Other Versions

Proposed For Comment Version 0.2